Application of 1945-84-2 ,Some common heterocyclic compound, 1945-84-2, molecular formula is C7H5N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Catalyst (3 mol%) and phenylacetylene (0.5 mmol) were added to 2 mL DMSO solution. The mixture was stirred at 50 C under 1 atm pressure O2 for 6 h. The progress of the reaction was monitored by TLC. After completion of the reaction, 10 mL of ethyl acetate was added. The mixture was filtered through a pad of diatomite under reduced pressure, and the filtration residue was washed with ethyl acetate. Ethyl acetate was removed under reduced pressure. The residue was then purified by column chromatography on silica gel using petroleum ether as eluent to afford the corresponding 1,3-diynes.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1945-84-2, its application will become more common.
Reference:
Article; Ma, Zongyan; Wang, Xiaoyu; Wei, Shuoyun; Yang, Honglei; Zhang, Fengwei; Wang, Peng; Xie, Miao; Ma, Jiantai; Catalysis Communications; vol. 39; (2013); p. 24 – 29;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem