In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6515-09-9, name is 2,3,6-Trichloropyridine, the common compound, a new synthetic route is introduced below. COA of Formula: C5H2Cl3N
To i-97 (30.0 g, 164 mmol, 1.00 eq.) in MeOH (300 mL)MeONa (10.9 g, 279 mmol, 1.70 equivalents) was added to the solution.The mixture was stirred at 70 C for 12 hours.The mixture was concentrated. Ethyl acetate (300 mL) and water (100 mL) were then added to the residue. The two phases were separated and the aqueous phase was extracted with ethyl acetate (2×100 mL).The combined organics were dried over anhydrous Na2SO4 filtered and concentrated. The residue was purified by silica gel column chromatography to give a solid.I-98 (22.7 g, 127 mmol) was used directly in the next step.
The synthetic route of 6515-09-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chuanru Pharmaceutical Corporation; R ·C·huoli; P ·yibulaxin; A ·P·fute; J ·R·gewoer; (117 pag.)CN108779119; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem