Related Products of 16110-09-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16110-09-1 as follows.
Step 1 Synthesis of Ethyl 5-chloropyridin-2-carboxylate: 1.2 g (8.2 mmol) of 2,5-dichloropyridine was dissolved in 50 ml of acetonitrile. 1.46 g (9.7 mmol) of sodium iodide and 0.7 ml (9.7 mmol) of acetyl chloride were added to the obtained solution, and they were stirred at 50 C. overnight. After the treatment with ethyl acetate as the extracting solvent by an ordinary method, the obtained crude product was dissolved in 15 ml of DMF. 182 mg (0.8 mmol) of palladium acetate, 147 mg (0.56 mmol) of triphenylphosphine, 2.3 ml of ethanol and 1.3 ml (9.7 mmol) of triethylamine were added to the obtained solution, and they were stirred in the presence of carbon monoxide at 70 C. overnight. After the treatment with ethyl acetate as the extracting solvent by an ordinary method, the obtained crude product was purified by the silica gel column chromatography to obtain the title compound. Yield: 250 mg (1.35 mmol) (16%) H-NMR (CD3Cl) delta 1.44 (3H, t), 4.47 (2H, d), 7.82 (1H, dd), 8.09 (1H, d), 8.69 (1H, d)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16110-09-1, its application will become more common.
Reference:
Patent; AJINOMOTO CO. INC; US2003/186969; (2003); A1;,
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