Related Products of 2897-43-0, Adding some certain compound to certain chemical reactions, such as: 2897-43-0, name is 2,6-Dichloro-3-nitropyridin-4-amine,molecular formula is C5H3Cl2N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2897-43-0.
Intermediate 3: 2,6-Dichloro-3,4-pyridinediamine; 2,6-dichloro-3-nitro-4-pyridinamine (881 mg, 4.24mmol) was taken up in ethanol (15ml) and tin(ll) chloride (3212mg, 16.94mmol) was added portion wise over 5min. The resulting pale yellow solution was allowed to stir at 50C under N2 for 3h, LCMS showed approx 60% conversion, the reaction was left for a further 3h, LCMS showed almost complete conversion. The reaction was allowed to cool to room temperature and was partitioned between NaHC03 (aq) (50ml) and EtOAc (50ml). The organic layer was dried using a hydrophobic frit, concentrated and dried in vacuo overnight to give the title compound as a yellow solid (734mg). LCMS (Method B): Rt = 0.57min, MH+ = 178
According to the analysis of related databases, 2897-43-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Francis Louis; ATKINSON, Stephen John; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander G; SHIPLEY, Tracy Jane; WILSON, David Matthew; WATSON, Robert J; WO2012/123312; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem