Adding a certain compound to certain chemical reactions, such as: 82671-06-5, 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H2Cl2FNO2, blongs to pyridine-derivatives compound. Formula: C6H2Cl2FNO2
CDI (35.6 g, 220 mmol) was added portionwise to a solution of C1 (42 g, 200 mmol) in THF (400 mL).The mixture was stirred for 5 min, protected with Ar, heated to 50 C, and reacted for 1 h.After LC-MS monitoring, the starting material disappeared, and the reaction mixture was diluted with toluene (100 mL) and concentrated to half of the original volume.The resulting mixture was cooled to 0 C and ammonium hydroxide (55 mL, 400 mmol) was slowly added.The reaction was carried out for 10 min at room temperature, diluted with EA (200 mL) and washed with water (100 mL*3).The organic layer was dried over anhydrous Na 2 SO 4 and dried. PE/EA (10/1, 200 mL) beaten, filtered,The remaining mother liquor was concentrated to half of the initial volume, cooled to 0 C, and the solid was again precipitated and filtered.The two crops were combined to give a pale-yellow solid product 74-1 (22.10 g, yield 53%).The primary product was used in the next reaction without purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,82671-06-5, 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Weijing Biological Pharmaceutical (Shanghai) Co., Ltd.; Fan Houxing; Xie Yuli; (72 pag.)CN110256421; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem