With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.88579-63-9, name is 2,6-Dichloropyridine-4-methylamine, molecular formula is C6H6Cl2N2, molecular weight is 177.0312, as common compound, the synthetic route is as follows.name: 2,6-Dichloropyridine-4-methylamine
[0918] A mixture of(28,58)-1-[(4-fluorobenzene)sulfonyl]-5-methylpynolidine-2-carboxylic acid (3 g, 10.44 mmol, 1.00 equiv), HATU (4.7 g, 12.36 mmol, 1.20 equiv), DIEA (2.6 g, 20.12 mmol, 2.00 equiv), and (2,6-dichloropyridin-4-yl)methanamine (2 g, 11.30 mmol, 1.10 equiv) in N,Ndimethylformamide (100 mL) was stirred for 1 h at room temperature. The resulting solution was diluted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by a silica gel colunm eluting with ethyl acetate/petroleum ether (1:1) to afford the title compound (3.6 g, 77%) as yellow oil. LCMS [M+H] 446.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,88579-63-9, 2,6-Dichloropyridine-4-methylamine, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; VOLGRAF, Matthew; CHEN, Huifen; KOLESNIKOV, Aleksandr; VILLEMURE, Elisia; VERMA, Vishal; WANG, Lan; SHORE, Daniel; DO, Steven; YUEN, Po-wai; HU, Baihua; WU, Guosheng; LIN, Xingyu; LU, Aijun; (537 pag.)WO2016/128529; (2016); A1;,
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