Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 582303-10-4, name is (2,6-Dimethylpyridin-3-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives
To a mixture of tri-n-butylphosphine (0.240 mL) , (2,6- dimethylpyridin-3-yl) methanol (92 mg) , methyl ( 6-hydroxy-4 , 7- dimethyl-l-benzofuran-3-yl) acetate (150 mg) and THF (6.0 mL) was added ADDP (242 mg) at room temperature. The mixture was stirred at room temperature overnight under nitrogen atmosphere. The mixture was concentrated. To the residue was added IPE and the precipitate was filtered off and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (163.9 mg) . XK NMR (300 MHz, CDC13) delta 2.33 (3H, s) , 2.54 (3H, s) , 2.55 (3H, s), 2.58 (3H, s), 3.73 (3H, s) , 3.80 (2H, d, J = 1.1 Hz), 5.04 (2H, s), 6.68 (1H, s) , 7.02 (1H, d, J = 7.6 Hz), 7.51 (1H, s) , 1.63 (1H, d, J = 7.9 Hz)
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Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKAKURA, Nobuyuki; BANNO, Yoshihiro; TERAO, Yoshito; OCHIDA, Atsuko; MORIMOTO, Sachie; KITAMURA, Shuji; TOMATA, Yoshihide; YASUMA, Tsuneo; IKOMA, Minoru; MASUDA, Kei; WO2013/125732; (2013); A1;,
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