Application of 886372-63-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 886372-63-0 as follows.
To a solution of 5-fluoro-6-methoxypyridin-3-amine (0.100 g, 0.704 mmol) in acetone (1 mL) was added dropwise benzoyl isothiocyanate (0. 104 mL, 0.774 mmol). The reaction mixture was all owed to stir at room temperature for 3 h. The reaction mixture was diluted with water and EtOAc. The layers were separated and the organic layer was washed with brine, dried with sodium sulfate, and concentrated under reduced pressure to yield Intermediate 1-21 A (0.215 g, 0.704 mmol, 100 % yield): 1H NMR (400MHz, CDCl3) delta 12,48 (brs, 1H), 9.12 (br s, 1 H), 8,06 (d, 2.0 Hz, 1H ). 8.01 (dd, J=10.8, 2,2 Hz, 1H), 7.91 (d, J=1.1Hz, 1 H), 7.89 (d, J = 1 .5 Hz, 1H), 7.71-7.65 (m, 1H), 7.60-7.54 (m, 2H), 4,06 (s, 3H), LC-MS: method H, RT = 1.18 rnin. MS (ESI) m/z: 306.1 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,886372-63-0, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; FU, Qinghong; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (184 pag.)WO2018/13770; (2018); A1;,
Pyridine – Wikipedia,
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