Reference of 1462-86-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1462-86-8, name is 3-Aminopicolinic acid, molecular formula is C6H6N2O2, molecular weight is 138.12, as common compound, the synthetic route is as follows.
Step B. 2-(I-Naphthalenyl)-H-pyrido[3,2-d][1,3]oxazin-4-one; 1-Naphthalenecarbonyl chloride (400 mg, 2.1 mmol) in CH2C12 (2 mL) was added into a solution of 3-amino-2-pyridinecarboxylic acid (277 mg , 2.0 mmol) and diisopropylethylamine (284 mg, 2.2 mmol) in DMF (10 mL) at 0 C. The reaction mixture was allowed to stir overnight at room temperature, and was then treated with diisopropylethylamine (284 mg, 2.2 mmol) and HATU (837 g, 2.2 mmol). After stirring for 1 h at room temperature, the reaction mixture was heated at 50 C to provide the title compound which was used in Step A. MS (ESI) (M+H)+ 274.79
Statistics shows that 1462-86-8 is playing an increasingly important role. we look forward to future research findings about 3-Aminopicolinic acid.
Reference:
Patent; AstraZeneca AB; WO2005/115987; (2005); A1;,
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