Electric Literature of 717843-51-1 , The common heterocyclic compound, 717843-51-1, name is 3-Bromo-2-methoxy-4-methylpyridine, molecular formula is C7H8BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 4: To a solution of compound 95 (990 mg, 4.9 mmol) in benzene (33 mL) was added NBS (870 mg, 4.9 mmol) followed by AIBN (40 mg, 0.25 mmol). The mixture was placed in an 80 C oil bath. After six hours, the reaction was diluted with EtOAc, washed with 1 M Na2C03 and brine, dried over MgS04, filtered and concentrated. The crude product was purified by flash chromatography eluting with heptanes/EtOAc (0-10%) to afford compound 96 as an oil (669 mg, 70% pure by NMR). 1H NMR (400 MHz, DMSO-d6) delta 8.14 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.68 (s, 2 H), 3.93 (s, 3 H).
The synthetic route of 717843-51-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; BAILEY, Simon; BURKE, Benjamin, Joseph; COLLINS, Michael, Raymond; CUI, Jingrong, Jean; DEAL, Judith, Gail; HOFFMAN, Robert, Louis; HUANG, Qinhua; JOHNSON, Ted, William; KANIA, Robert, Steven; KATH, John, Charles; LE, Phuong, Thi, Quy; MCTIGUE, Michele, Ann; PALMER, Cynthia, Louise; RICHARDSON, Paul, Francis; SACH, Neal, William; WO2013/132376; (2013); A1;,
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