Adding a certain compound to certain chemical reactions, such as: 116986-13-1, 3-(Bromomethyl)picolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3-(Bromomethyl)picolinonitrile, blongs to pyridine-derivatives compound. Recommanded Product: 3-(Bromomethyl)picolinonitrile
Using General Procedure A: A solution of 3,3″-dimethyl-1′,2′,3′,4′,5′,6′-hexahydro-cis-[2,2′;6′,2″]terpyridine (0.104 g, 0.39 mmol), 3-bromomethyl-pyridine-2-carbonitrile (0.115 g, 0.58 mmol), KI (23 mg, 0.14 mmol), and DIPEA (0.15 mL, 0.86 mmol) in DMF (4 mL) was heated at 60 C. for 20 hours. Purification of the crude material by column chromatography on silica gel (20:1:1 CH2Cl2-CH3OH-NH4OH) provided 133 mg (88%) of 3-(3,3″-dimethyl-3′,4′,5′,6′-tetrahydro-2’H-cis-[2,2′;6′,2″]terpyridin-1′-ylmethyl)-pyridine-2-carbonitrile as a tan solid.
The synthetic route of 116986-13-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chen, Gang; Crawford, Jason; Skerlj, Renato; US2005/154201; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem