Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 72990-37-5, name is 3-Chloroisonicotinaldehyde. A new synthetic method of this compound is introduced below., name: 3-Chloroisonicotinaldehyde
Preparation example 412: (E)-ethyl 3-(3-chl or opyr idiii-4-yl ) aery late 3-chloroisonicotinaldehyde (Preparation example 411, 0.54g, 3.79mmol) was dissolved in benzene. At the room temperature, triethyl phosphoacetate (753 f , 3.79mmol) and potassium tert-but oxide (468 mg, 4.17 mmol) were added and stirred. When the reaction was completed, the obtained product was washed with water and ethylacetate (EA) . Then, the organic layer was dehydrated with anhydrous magnesium sulfate (MgS04), filtrated, and concentrated under reduced pressure. The crude compound was purified by a silica gel column to produce the title compound (0.57g, 70~90%) . LH NMR (400MHz, CDC13) delta 1.40 (t, J = 12, 3H) 4.13 (q, J = 6.6, 2H) 6.61(d, J = 16.0, 1H).7.46 (cl, J = 16.0, 1H) 7.97 (d J = 8.0, 1H) 8.51 (d, J – 4.0, 1H) 8.66 (s, 1H)
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 72990-37-5, 3-Chloroisonicotinaldehyde.
Reference:
Patent; BIO-PHARM SOLUTIONS, CO., LTD.; CHOI, Yong Moon; WO2015/88271; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem