Related Products of 88511-27-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 88511-27-7, name is 4-Amino-3-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 3-iodopyridin-4-amine (6 g, 27.2 mmol) in dioxane (135 mL), (2,6-dichloropyridin-3-yl)boronic acid (7.29 g, 38.1 mmol), and 1M Na2CO3 aqueous solution (3 eq) were added andthe reaction mixture was degassed with argon for 20 mm. ThenBis(triphenylphosphine)palladium(ll) dichloride (3.79 g, 5.4 mmol) was added and the reactionmixture was heated at 100C for 16h. After completion of reaction, the reaction mixture wasfiltered through a celite pad and the filtrate was concentrated under reduced pressure to afford a residue that was dissolved in water and extracted with ethyl acetate. The organic layer was separated, dried over sodium sulphate and concentrated under reduced pressure to afford the crude product, which was further purified by silica gel (100:200 mesh) column chromatography toafford 2,6-dichloro-[3,3-bipyridin]-4-amine (ii) (2.9 g, Yield 44%).1H NMR (400 MHz, DMSO-d6) 66.04 (s, 2H), 6.62 (d, J= 5.8 Hz, 1H), 7.71 -7.55 (m, 1H), 7.94- 7.75 (m, 2H), 8.03 (d, J = 5.7 Hz, 1 H).MS (ESI) m/e (M+1): 240.05
According to the analysis of related databases, 88511-27-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UCB BIOPHARMA SPRL; MERCIER, Joel; VERMEIREN, Celine; (23 pag.)WO2018/24642; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem