Synthetic Route of 504-24-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.504-24-5, name is 4-Aminopyridine, molecular formula is C5H6N2, molecular weight is 94.12, as common compound, the synthetic route is as follows.
To a solution of 4-aminopyridine (50.0 g, 531 mmol) in triethylamine/CH2Cl2 (1:1, 200 mL) at 0°C was slowly added a solution of di-t-butyl-dicarbonate (116 g, 531 mmol) in CH2Cl2 (150 mL). The resulting mixture was allowed to warm to it overnight then was concentrated. The crude product was taken up in hot EtOAc, filtered and precipitated with hexanes. The precipitate was collected by filtration, washed with hexanes and dried under vacuum to give 91.0 g (88percent yield) of pure t-butyl carbamate.
The chemical industry reduces the impact on the environment during synthesis 504-24-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; PURDUE RESEARCH FOUNDATION; WO2007/61554; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem