Adding a certain compound to certain chemical reactions, such as: 131747-45-0, (4-Bromopyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: (4-Bromopyridin-2-yl)methanol, blongs to pyridine-derivatives compound. Recommanded Product: (4-Bromopyridin-2-yl)methanol
A mixture of 6-Bromo-lH-indazole (CAS No. 79762-54-2, 1.5 g, 7.6 mmol, 1.0 eq), 4- Bromo-2-pyridinemethanol (CAS No. 131747-45-0, 1.85 g, 9.9 mmol, 1.3 eq), Cul (285 mg, 1.5 mmol, 0.2 eq), K3P04 (3.2 g, 15.2 mmol, 2.0 eq) and 61798-24-1 (426 mg, 3.0 mmol, 0.4 eq) in 1,4-dioxane (15 mL) was stirred at 110 C for 16 h. After concentration, the residue was purified by silica gel chromatography using PE/EA (3/1) as eluent to give (4-(6-bromo- lH-indazol-l-yl)pyridin-2-yl)methanol as a yellow solid. 750 mg, Y: 32%. ESI-MS (M+H)+: 304.1
The synthetic route of 131747-45-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOGEN MA INC.; CHAN, Timothy; GUCKIAN, Kevin; JENKINS, Tracy; THOMAS, Jermaine; VESSELS, Jeffery; KUMARAVEL, Gnanasambandam; MEISSNER, Robert; LYSSIKATOS, Joseph; LUCAS, Brian; LEAF, Irina; DUFFIELD, Jeremy; (518 pag.)WO2016/11390; (2016); A1;,
Pyridine – Wikipedia,
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