A new synthetic route of 4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,930093-72-4, 4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.930093-72-4, name is 4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine, molecular formula is C11H10ClN3O, molecular weight is 235.6696, as common compound, the synthetic route is as follows.category: pyridine-derivatives

A solution of KOBut (2.4 mL, 1.0 M in THF, 2.34 mmol) was added to a solution of alcohol 50B (0.42 g, 1.95 mmol) and the chloride IB (0.56 g, 2.39 mmol) in anhydrous THF (10 mL) under nitrogen at 0 C and stirred at 0 C to room temperature for 16 hours. The reaction was quenched with saturated NH4Cl solution (15 mL) and extracted with EtOAc (30 mL * 3). The combined organic layer was dried over Na2SO4 and concentrated in vacuo. The residue was purified on a silica gel column (ISCO) with MeOH (NiH3) in dichloromethane (0-»5%) to provide compound 158 (0.81 g, 99% yield). LCMS: 416.5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,930093-72-4, 4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SCHERING CORPORATION; WO2009/55331; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem