A new synthetic route of 4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62002-31-7, its application will become more common.

Reference of 62002-31-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62002-31-7, name is 4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride. A new synthetic method of this compound is introduced below.

To a mixture of 4,5,6,7-tetrahydroimidazo[4,5-c]pyridine dihydrochloride (0.50 g, 2.55 mmol), ethanol (10 mL) and triethylamine (1.10 mL, 7.89 mmol), 2,4-dichlorobenzyl isocyanate (0.52 g, 2.57 mmol) was added. The resulting mixture was stirred at room temperature for 16 h and then concentrated under reduced pressure. The residue was distributed between water (20 mL) and ethyl acetate (75 mL). The organic phase was washed with water (10 mL) and brine (10 mL), dried (MgSO4) and concentrated under reduced pressure. The residue was triturated in diethylether (50 mL) and the crude product was filtered off. Recrystallization from acetone (25 mL) gave 0.30 g (37%) of the title ureaurea as a colourless solid. HPLC (214 nm): elution at 7.97 min. LC-MS: Calcd. for MH+: 325; found: 325. 1H NMR (400 MHz, DMSO-d6): delta2.56 (s, br, 2H), 3.65 (t, J=6 Hz, 2H), 4.29 (d, J=6 Hz, 2H), 4.34 (s, 2H), 7.20 (s, br, 1H), 7.29 (d, J=8 Hz, 1H), 7.39 (dd, J=8, 1 Hz, 1H), 7.47 (s, 1H), 7.56 (d, J=1 Hz, 1H), 11.79 (s, br, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62002-31-7, its application will become more common.

Reference:
Patent; Novo Nordisk A/S; US6908926; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem