A new synthetic route of 4,6-Dichloronicotinaldehyde

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1060811-62-2, 4,6-Dichloronicotinaldehyde, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1060811-62-2, Adding some certain compound to certain chemical reactions, such as: 1060811-62-2, name is 4,6-Dichloronicotinaldehyde,molecular formula is C6H3Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1060811-62-2.

Step B: 2-(4,6-difluoropyridin-3 -yl)-6-(trifluoromethyl)- 1 -H-benzimidazoleA solution of 4-(trifluoromethy)benzene-l ,2-diamine (250 mg, 1.419 mmol) in DMF (5.0 ml) and water (0.5 ml) was treated with the Intermediate from Step A (250 mg, 1.419 mmol) slowly and the mixture stirred at room temperature for 5 min. Potassium peroxymonosulfate (873 mg, 1.419 mmol) was then added and the mixture stirred for another 50 min. The mixture was poured slowly in 75 ml of water containing 6 ml (2 M K2CO3) and the mixture stirred at room temperature for 5 min. The mixture was diluted with EtOAc and the layers separated. The organic layer was dried (MgS04) and concentrated under vacuum. The resulting residue was then purification on the ISCO CombiFlash Companion (with a 24 g column) eluting with 20 to 40 percent ethylacetate / hexane gradient The desired fractions were concentrated to afford the title compound. LC-MS (ES> m/z) C13H6CI2F3N3: 332; Found: 332, 334, 336 [M, M+2.M+4].’HNMR (500 MHz, COCh, ppm) delta 7.58 (1H, s), 7.66 (1H, d, 8.5 Hz), 7.84 (1 H, d, 8.4 Hz), 8.08 (1H, s), 9.37 (1H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1060811-62-2, 4,6-Dichloronicotinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; BALKOVEC, James, M.; KRIKORIAN, Arto, D.; GUIADEEN, Deodial; YANG, Ginger; JIAN, Tianying; WU, Zhicai; YU, Yang; NARGUND, Ravi, P.; VACHAL, Petr; DEVITA, Robert, J.; HE, Shuwen; LAI, Zhong; BLEVIS-BAL, Radhika, M.; CERNAK, Timothy, A.; SPERBECK, Donald, M.; HONG, Qingmei; WO2012/96813; (2012); A1;,
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