4926-28-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4926-28-7, name is 2-Bromo-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
To 1.84 g ( 1 1.6 mmol) of KMn04 in 10 mL of H20 was added 0.65 mL (5.8 mmol) of 2-bromo-4-methylpyridine via syringe. The solution was refluxed for 1 hr, after which 1.25 equivalents ( 1.15 g; 7.25 mmol) of KMn04 was added. After an additional 2 hr reflux, 1.25 equivalents of KMn04 was added and stirred overnight to produce a dark solution containing a black suspension. After filtration through celite, the clear aqueous layer was washed with 3 x 20 mL of ethyl acetate. The aqueous layer was brought to a pH of 4 using 1M HC1 to precipitate out 237 mg of a white solid (yield = 20.3%). ESI-MS: m/z, 199.7 (calcd for M+ 199.9) NMR (DMSO-d6): delta 7.84 (dd, 1H, J = 5 Hz, l = lHz), 7.96 (s, 1H), 8.59 (d, 1H, J = 5 Hz), 14.02 (vbr, 1H).
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Reference:
Patent; BERLINGUETTE, Curtis P.; KOIVISTO, Bryan; ROBSON, Kiyoshi; WO2011/32269; (2011); A1;,
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