Application of 381233-75-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 381233-75-6, name is 5-Bromo-3-iodopyridin-2(1H)-one, molecular formula is C5H3BrINO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2 (9g, 3Ommol) was dissolved in phenyiphosphonic dichloride 90% (l0OmL,0.3mol). The mixture was stirred and heated (160C) for 4 hours and followed by TLC. At room temperature, it was introduced drops in a vial of 1 L filled with water and cooled at 0C. The solution was neutralized by addition of NH4OH solution. The mixture wasextracted in ethyl acetate. The product was obtained as a white solid, 5-bromo-2-chloro-3- iodopyridine 3 (yield: 82%),
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 381233-75-6, 5-Bromo-3-iodopyridin-2(1H)-one.
Reference:
Patent; CENTRE REGIONAL DE LUTTE CONTRE LE CANCER FRANCOIS BACLESSE; UNIVERSITE DE CAEN BASSE-NORMANDIE; INSTITUT DE CANCEROLOGIE DE L’OUEST RENE GAUDUCHEAU; POULAIN, Laurent; VOISIN-CHIRET, Anne-Sophie; SOPKOVA-DE OLIVEIRA SANTOS, Jana; BUREAU, Ronan; BURZICKI, Gregory; DE GIORGI, Marcella; PERATO, Serge; FOGHA, Jade; RAULT, Sylvain; JUIN, Philippe; GAUTIER, Fabien; WO2015/132727; (2015); A1;,
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