With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.929617-30-1, name is 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine, molecular formula is C7H6BrN3, molecular weight is 212.05, as common compound, the synthetic route is as follows.Recommanded Product: 929617-30-1
Step 4: To a solution of 5-bromo-3-methyl-lH-pyrazolo[3,4-c]pyridine (106 mg,0.5 mmol) in DMF (5 mL) was added Pd(dppf)Cl2 (20 mg), saturated solution of Na2C03 (1 mL) and lH-pyrazol-4-ylboronic acid (67 mg, 0.6 mmol). Under argon, the mixture was stirred under microwave irradiation for 1 h at 150 C. After cooling down, the solvent was removed under reduced pressure and the residue was purified by silica-gel column chromatography (mobile phase: EA:PE = 1 : 1) to afford 102 (15 mg, 15% ). 1H NMR (500 MHz, MeOD) 5 8.88 (s, 1H), 8.16 (m, 2H), 8.00 (s, 1H), 2.61 (s, 3H); ESI MS m/z = 200.1 (M+l)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,929617-30-1, 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; LEE, Wendy; TSUI, Vickie Hsiao-Wei; WANG, Xiaojing; WEN, Zhaoyang; WO2013/24002; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem