In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 886365-46-4, name is 5-Chloro-3-methylpyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. Quality Control of 5-Chloro-3-methylpyridine-2-carboxylic acid
Acid-16: 5-Chloro-4,6-dideutero-3-trideuteromethyl-pyridine-2-carboxylic acid; A suspension of 500 mg (2.91 mmol) 5-chloro-3-methyl-pyridine-2-carboxylic acid (CAS Nr.: 886365-46-4) in 9 ml of D20 (99,96% D) was treated with 1 ml of a 40% solution of NaOD in D20. The homogeneous solution was heated in a 100 ml Teflon vessel with a Synthos 3000 Microwave apparatus. The mixture was heated at 160 C for 5 h and cooled down. 1 H-NMR and MS analyses of the product showed that deuteration had progressed to a high degree. Only minor amounts of tetradeutero derivatives were present. The reaction mixture was acidified to pH3 with 2N HCI and extracted with EtOAc. The org. phase was dried with MgS04.H20 and evaporated to give the title compound as a white solid, pure enough for further transformations.HPLC: Rtm= 2.820 min; ESIMS [M+H]+ = 177 (5D);1H-NMR (360 MHz, D20): delta non deuterated impurities.
The synthetic route of 886365-46-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; HURTH, Konstanze; LUEOEND, Rainer Martin; MACHAUER, Rainer; NEUMANN, Ulf; RUEEGER, Heinrich; SCHAEFER, Michael; TINTELNOT-BLOMLEY, Marina; VEENSTRA, Siem Jacob; VOEGTLE, Markus; WO2012/95463; (2012); A1;,
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