Synthetic Route of 52313-50-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52313-50-5, name is Picolinimidamide. A new synthetic method of this compound is introduced below.
General procedure: To a solution of 2-(4-methyl-2-(naphthalen-2-yl)thiazol-5-yl)-5-(methylsulfonyl)-1,3,4-oxadiazole(9) (0.09 g, 0.25 mmol) in dry DMF (5 mL), the appropriateamine, hydrazine, guanidine or carboxamidine (0.4 mmol) was added.The reaction mixture was heated at 80 C for 0.5-12 h, and then pouredon ice water (50 mL). The formed solid was extracted with ethyl acetate(10 mL). The organic layer was evaporated under reduced pressure. Theobtained crude material was then purified by column chromatography.Physical properties and spectral analysis of isolated products are listed below:
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52313-50-5, its application will become more common.
Reference:
Article; Hannoun, Mohamed H.; Hagras, Mohamed; Kotb, Ahmed; El-Attar, Abdul-Aziz M.M.; Abulkhair, Hamada S.; Bioorganic Chemistry; vol. 94; (2020);,
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