5407-87-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5407-87-4, name is 2-Amino-4,6-dimethylpyridine, molecular formula is C7H10N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound 22. To a mixture of 1,3,5-tris(bromomethyl)-2,4,6-trimethyl-benzene (1b) (3.00 g, 6.80 mmol) and K2CO3 (1.88 g, 13.60 mmol) in CH3CN/THF (1:1 v/v; 40 mL) was added dropwise a CH3CN (10 mL) solution of 2-amino-4,6-dimethyl-pyridine (1.66 g, 13.60 mmol).The mixture was stirred at room temperature for 72 h. After filtration and evaporation of solvents, the crude product was purified by column chromatography (ethyl acetate/toluene, 1:3 v/v). Yield 30 %. M.p. 77-78 C. 1H-NMR (400 MHz, CDCl3) delta = 1.22 (t, 3H, J = 7.5 Hz), 1.29 (t, 6H, J = 7.5 Hz), 2.24 (s, 6H), 2.36 (s, 6 H), 2.73 (q, 2H, J = 7.5 Hz), 2.85 (q, 4H, J = 7.5 Hz), 4.23 (t, 2H, J = 4.2 Hz), 4.37 (d, 4H, J = 4.2 Hz), 4.62 (s, 2 H), 6.10 (s, 2 H), 6.35 (s, 2 H). 13C-NMR (100 MHz, CDCl3) delta = 16.4, 16.7, 21.1, 22.8, 23.0, 24.1, 29.6, 40.5, 103.6, 113.9, 131.9, 133.4, 143.8, 144.9, 148.9, 156.5, 158.0. HR-MS calcd for C29H39BrN4 5232.2353; found: 522.2360. Rf= 0.31 (ethyl acetate/toluene, 1:3 v/v).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5407-87-4, 2-Amino-4,6-dimethylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Technische Universitaet Carolo-Wilhelmina zu Braunschweig; EP1972627; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem