The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54453-93-9, name is Ethyl 2-Chloropyridine-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 54453-93-9
Stage a) (2-Chloropyridin-4-yl)methanol To a solution of 14.85 g of ethyl 2-chloroisonicotinate in 300 mL of ethanol are added, under argon, 9.08 g of sodium borohydride portionwise at 40 C. for 45 minutes. After addition, the reaction mixture is stirred for 15 minutes and the temperature is then gradually raised to reflux, which is maintained for 4 hours. After cooling to room temperature, 50 mL of saturated ammonium chloride solution are added and the solvents are evaporated off under reduced pressure. The residue is taken up in 200 mL of water and extracted with 3*100 mL of ethyl acetate, and the organic phase is washed with 2*100 mL of saturated sodium chloride solution, dried over sodium sulfate and filtered. After evaporation under reduced pressure, the product is obtained in the form of a white solid: 11.4 g. Rf TLC silica=0.38 (eluent: dichloromethane/methanol 90/10).
With the rapid development of chemical substances, we look forward to future research findings about 54453-93-9.
Reference:
Patent; AVENTIS PHARMA S.A.; US2009/82329; (2009); A1;,
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