Application of 5552-83-0 , The common heterocyclic compound, 5552-83-0, name is Ethyl 2-(6-methylpyridin-2-yl)acetate, molecular formula is C10H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A. Ethyl 6-methyl-3-pyridineacetate, N-oxide Ethyl 6-methyl-pyridineacetate (1.20 g, 6.70 mmol, 1 eq) was combined with 3-chloroperoxybenzoic acid (50percent, 2.77 g, 8.03 mmol, 1.2 eq) in 25 mL of CHCl3. The reaction mixture was stirred at rt for 4 h. The mixture was filtered twice through a 2 inch pad of Al2O3 eluding with 100 mL of 10percent methanol in CH2Cl2. Concentration in vacuo provided 1.29 g (99percent) of ethyl 6-methyl-3-pyridineacetate, N-oxide.
The synthetic route of 5552-83-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bristol-Myers Squibb Company; US6214852; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem