A new synthetic route of 5,6-Dichloronicotinonitrile

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65189-15-3, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 65189-15-3, 5,6-Dichloronicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 65189-15-3, blongs to pyridine-derivatives compound. Product Details of 65189-15-3

(a) tert-Butyl 4-(3-cWoro-5-cyanopyridin-2-yl)piperazine -1-carboxylate; 5,6-Dichloronicotinonitrile (5.00 g, 28.90 mmol, made in according to (JPN patent WO-95- JP587)), 1-Boc-piperazine (8.08 g, 43.4 mmol) and DIPEA (15.1 mL, 86.7 mmol) were suspended in DMA (50 mL) and heated at 120 C for 18 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure to afford the crude material. EPO The crude material was partitioned between DCM (300 mL) and saturated aqueous NaHCO3 (150 mL) and the organics separated. The organics were washed with water (150 mL) and then dried (Mg5O^ and concentrated under reduced pressure to afford the crude product.Flash chromatography (DCM) gave tert-butyl 4-(3-chloro-5-cyanopyridin-2-yl)piperazine-1- carboxylate as a solid. Yield: 11.2O g (120 %) The product was contaminated with DMA. 1HNMR (400 MHz, CDCl3): 6 1.49 (9H, s), 3.52-3.62 (8H, m), 7.76 (1H, s), 8.39 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65189-15-3, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2006/73361; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem