As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13534-97-9, name is 6-Bromopyridin-3-amine, molecular formula is C5H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C5H5BrN2
2. Preparation of diethyl 2-((6-bromopyridine-3-ylamino)methylene)malonate 6-bromopyridine-3-amine (74g, 0.43mol) and diethyl ethoxymethylenemalonate (100mL) were added ethanol (680mL). The mixture is reacted under heating to reflux for 5h. The reaction mixture was cooled. The solid was separated out and filtered by suction. The resulting solid was washed with petroleum ether to produce 125.4g of the title compound as a pale-yellow solid in a yield of 85.2%.
With the rapid development of chemical substances, we look forward to future research findings about 13534-97-9.
Reference:
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; ZHANG, Yan; EP2719697; (2014); A1;,
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