A new synthetic route of 6-Bromopyridin-3-amine

The synthetic route of 13534-97-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 13534-97-9, 6-Bromopyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 13534-97-9, blongs to pyridine-derivatives compound. SDS of cas: 13534-97-9

To a solution of 6-bromopyridin-3-amine (500 mg, 2.89 mmol) in CH3CN:DMF (3:2 mL) was added CuI (219 mg, 1.15 mmol) and triethylamine (2 mL, 14.4 mmol) and the solution was purged with argon for 15 min. Ethynyltrimethylsilane (1.2 mL, 8.67 mmol) and tetrakis(triphenyl phosphine)Pd(0) (100 mg, 0.086 mmol) were added and the solution was purged for another 30 min. The reaction mixture was heated to 45C for 2.5 h. Then, the reaction mixture was diluted with ethyl acetate (100 mL) and washed with saturated NaHCO3 solution (50 mL). The aqueous layer was re-extracted with ethyl acetate (3 X 50 mL). The combined organic layer was washed with water (2 X 50 mL), followed by brine and dried over sodium sulphate and concentrated in vacuo to afford 6-((trimethylsilyl)ethynyl)pyridin-3-amine 5 (776mg, 70percent).1H NMR (400 MHz, CDCl3) delta 8.04 (s, 1H), 7.25 (d, J=7.8 Hz, 1H), 6.91(d, J=7.8 Hz, 1H), 3.85 (br s, 2H), 0.24 (s, 9H). ES-MS m/z 191.00 (M+H)+.

The synthetic route of 13534-97-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LYSOSOMAL THERAPEUTICS INC.; SKERLJ, Renato, T.; LANSBURY, Peter, T.; GOOD, Andrew, C.; BOURQUE, Elyse Marie, Josee; (134 pag.)WO2016/73889; (2016); A1;,
Pyridine – Wikipedia,
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