Application of 5350-93-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5350-93-6, name is 6-Chloropyridin-3-amine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.
A mixture of 3-amino-6-chloropyridine (12.5 g, 98 mmol) and potassium thiocyanate (80 g, 820 mmol) in glacial acetic acid (200 mL) was cooled with ice bath. Bromine (0.6 mL, 11.6 mmoi) was added dropwise. The resulting mixture was stirred at O°C for 1 h and room temperature overnight. Water (100 mL) was added to the mixture, and heated at 85°C. The mixture was filtered, while stifl warm. The solid was collected and washed with warm acetic acid. The combined filtrate was brought to basic by careful addition of ammonium hydroxide. DCM was added to the mixture. The aqueous layer was separated and extracted with DCM. The organic layer was combined, dried (MgSO4), filtered and concentrated. The residue was purified with silica gel column to give 11.2 g (61percent) of a white solid as the desired product 164a.
The chemical industry reduces the impact on the environment during synthesis 5350-93-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SCHERING CORPORATION; PALANI, Anandan; RAO, Ashwin, U.; CHEN, Xiao; SHAO, Ning; HUANG, Ying, R.; ASLANIAN, Robert, G.; WO2010/71819; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem