Synthetic Route of 6271-78-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6271-78-9 as follows.
To a solution of 6-chloronicotinamide (20.0 g,128.20 mmol) in MeOH/ THF/ DMF (40/20/10.0 mL) was added 2M methyl amine solutionin THF (96.0 mL, 192.3 mmol) and heatedin a sealed bomb at 80 C for 12 h. After completion of the reaction thereaction mixture was concentrated under reduced pressure, the crude waspurified on Combiflash purifier with 6% Methanol in Dichloromethane as eluentto afford the title compound as off-white solid (6.0 g, 31%). 1H NMR(DMSO-d6, 400 MHz) delta 2.78 (d, J= 4.4 Hz, 3H), 6.39 (d, J = 8.0 Hz,1H), 6.93-6.94 (m, 2H), 7.60 (bs, 1H), 7.78 (dd, J = 2.0 Hz, J = 2.0 Hz,1H), 8.50 (d, J = 1.6 Hz, 1H); MS (ESI) m/z 152.1 (M+H)+; HPLC Purity 215nm, 99.15%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6271-78-9, its application will become more common.
Reference:
Article; Ruf, Sven; Hallur, Mahanandeesha Siddappa; Anchan, Nisha K.; Swamy, Indu N.; Murugesan, Karthikai Raj; Sarkar, Sayantani; Narasimhulu, Lokesh Kananti; Putta, V.P. Rama Kishore; Shaik, Shama; Chandrasekar, Devaraj Venkatapura; Mane, Vishal Subhash; Kadnur, Sanjay Venkatachalapathi; Suresh, Juluri; Bhamidipati, Ravi Kanth; Singh, Manvi; Burri, Raghunadha Reddy; Kristam, Rajendra; Schreuder, Herman; Czech, Joerg; Rudolph, Christine; Marker, Alexander; Langer, Thomas; Mullangi, Ramesh; Yura, Takeshi; Gosu, Ramachandraiah; Kannt, Aimo; Dhakshinamoorthy, Saravanakumar; Rajagopal, Sridharan; Bioorganic and Medicinal Chemistry Letters; vol. 28; 5; (2018); p. 922 – 925;,
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