Application of 133081-24-0 ,Some common heterocyclic compound, 133081-24-0, molecular formula is C6H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
6-chloronicotinic acid (1.6 g ) in MeOH (1OmL) was treated with NH2NH2 (2 g) at 140 0C for 2h. After cooling to -20 0C, the solid was filtered to give 560mg of compound 33B. Compound 33B was treated with isothiocyanatobenzene (141 mg) in 1 ,2-dichlorobenzene (5 mL) at 100 0C for 10 min, and then 180 0C for Ih. The product was purified by LCMS to give 3-mercapto- [l,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (450mg). ESI-MS:m/z 196.1 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 133081-24-0, 6-Hydrazinylnicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BRESSI, Jerome, C.; CHU, Shaosong; ERICKSON, Philip; KOMANDLA, Mallareddy; KWOK, Lily; LAWSON, John, D.; STAFFORD, Jeffrey, A.; WALLACE, Michael, B.; ZHANG, Zhiyuan; DAS, Sanjib; WO2010/19899; (2010); A1;,
Pyridine – Wikipedia,
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