Application of 1620-75-3, Adding some certain compound to certain chemical reactions, such as: 1620-75-3, name is 6-Methylpicolinonitrile,molecular formula is C7H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1620-75-3.
Synthesis of 2-bromomethyl-6-cyanopyridine or compound 7 A solution of 400 mg (3.39 mmol) of 2-cyano-6-methylpyridine in 12 ml of CHCl3 is admixed with 723 mg (4.06 mmol) of N-bromosuccinimide (NBS) and 28 mg (0.17 mmol) of azobisisobutyronitrile (AIBN). The resulting orange-brown suspension is refluxed and irradiated with a UV lamp for 4 hours (the reaction is monitored by TLC on silica plates, using CH2Cl2 as eluant-Rf=0.43). The reaction mixture is cooled to ambient temperature and the solvent is evaporated under reduced pressure. The crude product is purified by chromatography on a silica gel column, using a continuous gradient from an 85/15 v/v CH2Cl2/heptane mixture to pure CH2Cl2 as eluant. This gives 290 mg of compound 7 in the form of a white microcrystalline powder (yield: 43%). 1H NMR (200 MHz, CDCl3) delta ppm: 4.55 (s, 2H, pyCH2Br), 7.63 (dd, J=7.63, 1.27 Hz, 1H, H3), 7.70 (dd, J=7.95, 1.27 Hz, 1H, H1), 7.87 (t, J=7.95Hz, 7.63Hz, 1H, H2).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1620-75-3, 6-Methylpicolinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Giraud, Marion; Demadrille, Renaud; Mazzanti, Marinella; Andreiadis, Eugen Sorin; US2011/112289; (2011); A1;,
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