A new synthetic route of 64064-71-7

The synthetic route of 64064-71-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 64064-71-7, name is 6-Bromo-3-nitroimidazo[1,2-a]pyridine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C7H4BrN3O2

To a suspension of 6-bromo-3-nitro-imidazo[1,2-a]pyridine (535 mg, 2.21 mmol) in DME (5 ml) was added 1,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one (prepared using the procedure described in US20130053362, 661 mg, 2.65 mmol), Cs2CO3 (1.8 g, 5.53 mmol), Pd(PPh3)4 (256 mg, 0.22 mmol) and water (1 ml). The reaction mixture was degassed with N2 and then heated in a sealed tube at 90C for 18 h. The mixture was cooled to rt and the resulting solid was collected by filtration, washed with water and dried under vacuum to afford the title compound (472 mg, 75%), which was used directly in the next step without further purification. 1H NMR (500 MHz, DMSO) delta 9.39 (s, 1H), 8.78 (s, 1H), 8.17 (d, J=2.5 Hz, 1H), 8.06-7.98 (m, 2H), 7.78 (d, J=1.4 Hz, 1H), 3.55 (s, 3H), 2.11 (s, 3H); MS (ESI) [M+H]+ 285.2;

The synthetic route of 64064-71-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEOMED INSTITUTE; POURASHRAF, Mehrnaz; BEAULIEU, Marc-Andre; CLARIDGE, Stephen; BAYRAKDARIAN, Malken; JOHNSTONE, Shawn; ALBERT, Jeffrey S.; GRIFFIN, Andrew; (135 pag.)WO2017/66876; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem