Adding a certain compound to certain chemical reactions, such as: 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 69045-84-7, blongs to pyridine-derivatives compound. Quality Control of 2,3-Dichloro-5-(trifluoromethyl)pyridine
EMBODIMENT 13: Preparation of ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate To a 500 mL three-necked flask equipped with a thermometer was added 200 g DMSO, 25 g potassium hydroxide and 24 g ethyl 2-cyanoacetate. 44 g 2,3-dichloro-5-(trifluoromethyl)pyridine was added while the reaction temperature was controlled within 50 C. After addition, the reaction was continued for 1 hour. After the reaction was complete, the solvent was removed. Water was added. The mixture was acidified with hydrochloric acid, filtered, washed with water, dried to produce 85 g ethyl ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate in 97% yield. 1H-NMR deltappm(CDCl3): 8.6(s, 1H), 6.27(s, 1H), 4.25(d, J=5.6 Hz, 2H), 3.40(br, 1H), 1.2 (t, J=5.6 Hz, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69045-84-7, its application will become more common.
Reference:
Patent; ZHEJIANG ZHUJI UNITED CHEMICALS CO., LTD; Su, Yehua; Shi, Jieping; Lu, Jianxin; Zhang, Tianhao; Yu, Xiaohua; Cai, Guoping; Chen, Bangchi; (7 pag.)US2017/369412; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem