Related Products of 72093-04-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72093-04-0, name is 3-Chloro-4-methylpyridine, molecular formula is C6H6ClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under the protection of nitrogen,Add (0.188 mmol) to the reaction flask in turn.[Ir(COD)Cl] 2 (1,5-cyclooctadiene chloride dimer),R-(+)-1,1′-binaphthyl-2,2′-diphenylphosphine (0.188 mmol),150ml of dichloromethane,Stir at room temperature for 20 min,Then add potassium iodide 20.07g (0.0938mol)And 11.96 g (0.0938 mol) of 3-chloro-4-methylpyridine,The reaction flask was placed in a stainless steel autoclave and replaced with hydrogen three times.Finally, the required hydrogen pressure is 200 psi.After reacting for 12 hours at room temperature,Slowly release hydrogen,The reaction system was diluted with 150 mL of dichloromethane.Add 150 mL of saturated sodium carbonate solution, stir for 15 min, and separateOrganic layer,The aqueous layer was extracted with dichloromethane (3×150 mL).The organic layers were combined and dried over Na 2 SO 4 .The solvent was removed to give Compound III 16.84 g.The yield was 82.3%, and the HPLC purity was 99.55%.The ee value is 82%.
According to the analysis of related databases, 72093-04-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Song Lili; Meng Fanna; Liu Mingming; (8 pag.)CN108948021; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem