Related Products of 882033-66-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 882033-66-1, name is 4-Chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H4ClFN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 222A mixture of 4-chloro-5-fluoro-lH-pyrrolo [2, 3-b] pyridine (30 mg) and cyclohexylamine (87 mg) in DMI(O.4 mL) was heated in the microwave reactor (2000C, 4 hours) . The reaction mixture was allowed to cool to ambient temperature and diluted with EtOAc (10 mL) and half-saturated aqueous sodiumhydrogencarbonate (1OmL) . The aqueous phase was extracted with EtOAc (2x 10 mL) and combined organic layers were washed with brine (20 mL) , dried over MgSO4, and concentrated. Purification of the crude product by preparative silica gel thin-layer chromatography (EtOAc) gave N-cyclohexyl-5-fluoro- lH-pyrrolo [2, 3-b]pyridin-4-amine (5 mg) as a yellow solid. 1H-NMR (CDCl3) delta: 9.90 (IH,br) , 7.95 (IH, d, J=4.4Hz) , 7.14 (IH, d, J=3.4Hz) ,6.50(lH,d,J=3.4Hz),4.46(lH,br) , 3.90-3.80 (IH,m) ,2.2-1.2 (1OH,m) . MS(ESI) :m/z 234(M+H)+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 882033-66-1, 4-Chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine.
Reference:
Patent; ASTELLAS PHARMA INC.; WO2007/7919; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem