Synthetic Route of 89570-82-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89570-82-1, name is 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine, molecular formula is C6H5ClF3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In 250mL reaction flask, 3-chloro-5- (trifluoromethyl) -2- (2- (2- (trifluoromethyl) phenyl) hydrazino) pyridine 16.92g (0.08mol), 120mL acetonitrile and 9.7g (0.096mol) of triethylamine acid-binding agent, with stirring, a solution of 18.34g (0.088mol) o-trifluoromethyl-benzoyl chloride under ice-cooling.Under ice-cooling, the reaction 1h, TLC monitored the reaction to completion.Amount of ice water was added, a lot of white solid was precipitated, filtered off with suction to give 26.5 g of a white solid, a yield of 93.18%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89570-82-1, 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine.
Reference:
Patent; Qingdao University of Science and Technology; Xu Liangzhong; Liu Liancai; Sun Jianxin; Cui Huanqi; Wang Minghui; (6 pag.)CN109232550; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem