Application of 934279-60-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 934279-60-4, name is 2-Chloro-5-(trifluoromethyl)nicotinaldehyde. A new synthetic method of this compound is introduced below.
To a stirred solution of 427 2-chloro-5-(trifluoromethyl)nicotinaldehyde (780 mg, 3.72 mmol) in 139 MeOH (5 mL) was added 100 NaBH4 (141 mg, 3.72 mmol) at 0 C. and the reaction was stirred at 0 C. for 1 h. The reaction mixture was quenched with sat. 101 NH4Cl (5 mL), then extracted with EtOAc (5 mL×2). The organic layers were collected, washed with brine, dried over Na2SO4, filtered, and the filtrate was concentrated in vacuo. The residue was purified by flash silica gel chromatography to give the 429 title compound as an oil. MS (ESI) m/z: 212.0 [M+H+].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,934279-60-4, its application will become more common.
Reference:
Patent; Merck Sharp & Dohme Corp.; Han, Yongxin; Achab, Abdelghani; Deng, Yongqi; Fradera, Xavier; Gibeau, Craig; Hopkins, Brett A.; Li, Derun; Liu, Kun; McGowan, Meredeth A.; Sciammetta, Nunzio; Sloman, David; White, Catherine; Zhang, Hongjun; Zhou, Hua; US2019/144433; (2019); A1;,
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