Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 936011-17-5, name is 5-Bromo-2-methoxyisonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives
Step B: methyl 4-formyl-6-methoxynicotinate (39-2)To a solution of compound 39-1 (30 g, 139 mmol) and Et3N (27 g, 280 mmol) in 100 mL of methanol was added Pd(dppf)C12 (10.5 g, 139 mmol). The resulting mixture was stirred underCO (50 Psi) at 70 C for 12 hours. After cooling, filtration and concentration, the resulting residue was purified by column chromatography on silica gel (eluted with petroleum ether:ethyl acetate= 3:1) to give 39-2. MS(ESI) mle (M+Hj: 196.0.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William, K.; NARGUND, Ravi, P.; BLIZZARD, Timothy, A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher, W.; DANG, Qun; LI, Bing; LIN, Linus, S.; CUI, Mingxiang; HU, Bin; HAO, Jinglai; CHEN, Zhengxia; WO2014/22528; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem