Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1061357-87-6, name is 6-Bromo-4-iodonicotinonitrile. A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Bromo-4-iodonicotinonitrile
To a solution of Intermediate 10A (0.60 g, 1.94 mmol) in a mixture of toluene (10 mL) and water (2 mL) was added cyclopropylboronic acid (0.20 g, 2.33 mmol) followed by K3PO4 (0.82 g, 3.88 mmol) and the resulting mixture was degassed for 15 minutes. Palladium(II) acetate (0.05 g, 0.19 mmol) and tricyclohexylphosphine (0.11 g, 0.39 mmol) ware added. The resulting mixture was degassed again for 10 minutes and heated at 140 C for 1 h in the microwave. The reaction mixture was cooled to ambient temperature and filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (Redisep12 g, 1520% EtOAc/nHexanes) to obtain Intermediate 10 (0.10 g, 23.08 %) as a yellow solid. 1H NMR (400 MHz, DMSOd6) G^ppm 0.93 1.02 (m, 1 H), 1.04 1.13 (m, 1 H), 1.19 1.35 (m, 2 H), 2.05 2.21 (m, 1 H), 8.51 (s, 1 H), 8.75 (s, 1 H). LCMS (MethodD): retention time 2.25 min, [M+2H] 223.0.
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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YADAV, Navnath Dnyanoba; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; GUNAGA, Prashantha; PANDA, Manoranjan; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (444 pag.)WO2018/222795; (2018); A1;,
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