Related Products of 40296-46-6 ,Some common heterocyclic compound, 40296-46-6, molecular formula is C8H7Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Sodium hydroxide (40 mL, 6.25 M solution) was added to a stirred solution of 4,6-dichloronicotinic acid ethyl ester (22) (25.95 g, 118 mmol) in 4:1:1 THF:MeOH:water (600 mL). After 30 minutes, the reaction mixture was acidified to pH 2 with concentrated HCl, diluted with 1:1 EtOAc:Et2O and washed with water and brine. The organic layer was dried (Na2SO4) and concentrated. The resulting off-white solid was twice concentrated from toluene to give the desired product (23) as a white solid (21.73 g, 96%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 40296-46-6, Ethyl 4,6-dichloronicotinate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Wallace, Eli; Hurley, Brian; Yang, Hon Woon; Lyssikatos, Joseph; Blake, Jim; US2005/49419; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem