Adding a certain compound to certain chemical reactions, such as: 81803-60-3, Ethyl imidazo[1,5-a]pyridine-3-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 81803-60-3, blongs to pyridine-derivatives compound. Recommanded Product: 81803-60-3
2-(Aminomethyl)pyridine (1.5 g, 13.9 mmol) and pyridine (5.55 g, 59.6 mmol) were dissolved in MeCN (30 mL), and the solution was cooled by using an ice bath. A solution of ethyl oxalyl chloride (1.89 g, 13.9 mmol) in MeCN (10 mL) was added dropwise at 0 to -5 C. After the addition, the mixture was stirred for 2 h and a solution of TFAA (6.41 g, 30.5 mmol) in MeCN (15 mL) was added dropwise at -15 to -10 C (ice-salt bath). The reaction mixture was allowed to stand overnight in the bath, then the mixture was poured in sat. aq sodium hydrocarbonate, filtered, and washed with water. Yield: 3.77 g (95%); yellow solid; mp 225 C. 1H NMR (DMSO-d6): delta = 1.40 (t, J = 6.6 Hz, 3 ), 4.48 (q, J = 6.6 Hz, 2 H), 7.51 (t, J = 6.6 Hz, 1 H), 7.86 (t, J = 7.6 Hz, 1 H), 8.40 (d, J = 8.8 Hz,1 H), 9.45 (d, J = 6.6 Hz, 1 H). 13C NMR (DMSO-d6): delta = 14.2, 61.7, 116.6 (q, 1JC-F = 290.7 Hz), 118.5, 118.6, 123.1, 128.0, 129.1, 132.2, 139.0, 158.4, 172.9 (q, 2JC-F = 33.9 Hz). MS: m/z (%) = 288 (14) [M + 2]+, 287 (100) [M + 1]+, 259 (3) [M + 2 -CO]+, 242 (3) [M + 2 – C2H5OH]+, 241 (23) [M + 1 – C2H5OH]+.
The synthetic route of 81803-60-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tverdiy, Dmytro O.; Chekanov, Maksym O.; Savitskiy, Pavlo V.; Syniugin, Anatolii R.; Yarmoliuk, Sergiy M.; Fokin, Andrey A.; Synthesis; vol. 48; 23; (2016); p. 4269 – 4277;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem