Reference of 6200-60-8, Adding some certain compound to certain chemical reactions, such as: 6200-60-8, name is Imidazo[1,2-a]pyridine-3-carboxylic acid,molecular formula is C8H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6200-60-8.
To a solution of imidazo[1,2-a] pyridine-3-carboxylic acid (250 mg) in DMF (7 mL), EDCI (443 mg, 1.5 equiv.), HOBt (312 mg, 1.5 equiv.), DIPEA (805 muL, 3.0 equiv.) and compound 73 (404 mg, 1.0 equiv.) were added. The resulting mixture was stirred at R.T. overnight. The reaction mixture was diluted with AcOEt (15 mL), washed with HCl 1M (2*10 mL) and water (2*10 mL). Combined aqueous layers were saturated with NaHCO3 and extracted with AcOEt (2*10 mL). The combined organic layers were washed with brine, dried over MgSO4 and concentrated under reduced pressure. Purification by flash-chromatography (MeOH 2% to 5% in CH2Cl2) followed by preparative HPLC afforded the product as a white solid (9.3 mg, yield <5%). 1H-NMR (400 MHz, DMSO): 1.11-1.79 (m, 13H, 5*CH2 + CH3); 3.33 (q, J 7.0 Hz, 2H, N-CH2); 6.81 (dd, J 1.9 Hz, J 8.1 Hz, 1H, Ar); 6.90 (d, J 2.0 Hz, 1H, Ar); 7.20 (m, 1H, Ar); 7.55 (m, 1H, Ar); 7.75-7.78 (m, 2H, Ar); 8.56 (s, 1H, Ar); 9.36 (bs, 1H, NH); 9.47 (m, 1H, Ar). N-CH signal under water peak. M/Z (M+H)+ = 407.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6200-60-8, Imidazo[1,2-a]pyridine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Domain Therapeutics; EP2210891; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem