In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145335-90-6, name is Imidazo[1,2-a]pyridine-8-carboxylic acid hydrochloride, the common compound, a new synthetic route is introduced below. Safety of Imidazo[1,2-a]pyridine-8-carboxylic acid hydrochloride
Step B: Preparation of Imidazo[l,2-alpha]pyridine-2-carbonyl chloride Hydrochloride. Method 1: To imidazo[l,2-alpha]pyridine-8-carboxylic acid hydrochloride (10.0 g, 50.4 mmol), thionyl chloride (98 g, 60 mL, 822 mmol) was added. To the resulting mixture N,N- dimethylformamide (1.6 mL) was added. Gas evolution was noticed and the reaction mixture was heated to 50 0C overnight (18 h). The reaction mixture was then cooled to room temperature and the product was filtered and washed with isopropyl acetate (40 mL) followed by 10% isopropanol in isopropyl acetate (40 mL). The white solid thus obtained was dried under reduced pressure to afford the title compound (10.2 g, 93%). The compound was used without further purification in Step E.
The synthetic route of 145335-90-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARENA PHARMACEUTICALS INC.; WO2009/23253; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem