Adding a certain compound to certain chemical reactions, such as: 55-22-1, Isonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55-22-1, blongs to pyridine-derivatives compound. Safety of Isonicotinic acid
General procedure: A mixture of o-aminobenzenethiol (1 mmol), carboxylic acid (1 mmol), N,N-diisopropylethylamine (1.5 mmol) and propylphosphonic anhydride (1 mmol, 50% w/w in AcOEt) was irradiated for 10 min under microwave at 100 C in a sealed tube. It was diluted with H2O, followed by alkalinization with saturated aqueous NaHCO3 solution. The precipitate was collected by filtration and washed thoroughly with H2O to afford the respective benzothiazole. If necessary, simple recrystallization was carried out in EtOH/H2O.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55-22-1, its application will become more common.
Reference:
Article; Wen, Xiaoan; Bakali, Jamal El; Deprez-Poulain, Rebecca; Deprez, Benoit; Tetrahedron Letters; vol. 53; 19; (2012); p. 2440 – 2443;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem