Synthetic Route of 623585-74-0 ,Some common heterocyclic compound, 623585-74-0, molecular formula is C7H5Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A 3N methylmagnesium bromide solution in ether (5.6 ml) was added dropwise to a mixture of methyl 2,5- dichloroisonicotinate (2.90 g) , iron (III) acetylacetonate (0.25 g) , THF (85 ml) and N-methylpyrrolidone (8.5 ml) under ice-cooling, and this was stirred at the same temperature for 1 hour. After an aqueous saturated sodium chloride solution (100 ml) was added to the reaction mixture, this was extracted with ethyl acetate, and the ethyl acetate layer was washed with an aqueous saturated sodium chloride solution, dried over magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate-hexane) to obtain the desired product (1.82 g) as an oil.1H-NMR (CDCl3) delta 2.52 (3H, s) , 3.99 (3H, s), 7.74 (IH, s) ,8.34 (IH, s) .
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623585-74-0, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2006/64944; (2006); A1;,
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