Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1122-71-0, name is 6-Methyl-2-pyridinemethanol. A new synthetic method of this compound is introduced below., Product Details of 1122-71-0
EXAMPLE 5 3.00 g (0.0244 mol) of 6-methyl-2-pyridinemethanol, 0.076. g of PIPO obtained in Reference Example 1 (2,2,6,6-tetramethylpiperidine-1-oxyl-4-yl group: 0.000244 mol), 6.0 g of toluene and 3.0 g of a 5% by weight aqueous solution of sodium hydrogen carbonate (sodium hydrogen carbonate: 0.0018 mol) were placed in a 100 ml reaction vessel. Then, with maintaining the temperature at 15 to 20 C., reaction was conducted while 13.5 g of a 13.4% by weight aqueous solution of sodium hypochlorite (sodium hypochlorite: 0.0244 mol) was dropped over 4 hours by a microsyringe pump under stirring. Stirring was conducted for another 0.5 hour to complete the reaction. The reaction mixture after the reaction was completed was separated into the organic phase and the water phase and each phase was analyzed by liquid chromatography. By the reaction, 6-methyl-2-pyridinecarbaldehyde was produced with yield of 94.9% (based on 6-methyl-2-pyridinemethanol). As a by-product, 3.1% (based on 6-methyl-2-pyridinemethanol) of 6-methylpicolinic acid was produced.
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Reference:
Patent; Shiomi, Yasuhiro; Uno, Osamu; Ohta, Akio; Sunakami, Takeshi; US2005/124807; (2005); A1;,
Pyridine – Wikipedia,
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