A new synthetic route of Pyridine-3-sulfonyl chloride

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16133-25-8, name is Pyridine-3-sulfonyl chloride, molecular formula is C5H4ClNO2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of Pyridine-3-sulfonyl chloride

I4- |2-(2,4-dichlorophenyl)-5-methyl-4-[(piperidin- 1 -ylamino)carbonvil- lH-imidazol- 1 – vUphenyl pyridine-3 -sulfonate 2-(2,4-Dichlorophenyl)- 1 -(4-hydroxyphenyl)-5-methyl-N-piperidin- 1 -yl- lH-imidazole-4- carboxamide, prepared as described in B, Step 1 (100 mg, 0.22 mmol) and triethylamine (0.31 ml, 2.25 mmol) in dichloromethane (5.0 ml) were cooled to -780C. 3- Pyridinesulfonyl chloride (144 mg, 0.67 mmol) was added in small portions to the reaction EPO mixture. The resulting mixture was stirred at -78¡ãC for Ih, and at room temperature overnight. Water was added to the reaction, the phases were separated and the organic phase washed with water and dried. The solvent was removed under reduced pressure and separation by preparatory HPLC gave the title compound (110 mg, 84percent) as a solid. s 1H NMR (400 MHz) delta 8.96 (s, IH), 8.92 (s, IH), 8.09-8.06 (m, IH), 7.89 (s, IH), 7.51- 7.49 (m, IH), 7.36 (d, IH), 7.30-7.25 (m, 2H), 7.06 (s, 4H), 2.88-2.84 (m, 4H), 2.48 (s, 3H), 1.79-1.74 (m, 4H), 1.47-1.41 (m, 2H). MS m/z 586 (M+H)+.

With the rapid development of chemical substances, we look forward to future research findings about 16133-25-8.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/31720; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem