In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 696-54-8, name is Pyridine-4-aldoxime, the common compound, a new synthetic route is introduced below. Formula: C6H6N2O
General procedure: To a mixture of oxime (0.86mmol) and Raney Co 2724 (200 mg, slurry in H2O) were addedTHF (1.5 mL) and MeOH (1.5 mL). The reaction mixture waspurged with nitrogen twice then pressurized to 60 psi H2 at 50C. The reaction was deemed complete when H2 consumptionceased, typically after 2-10 h. Upon completion, the reactionwas filtered through a pad of celite and washed with MeOH. Thefiltrate was then concentrated under reduced pressure, andpurified by flash chromatography (CH2Cl2-MeOH, 95:5) tofurnish the title compound. Alternatively, the product was convenientlyisolated in high purity as the HCl salt. After filteringoff the catalyst, the filtrate solvent was changed to MTBE (1.5mL) and HCl (0.95 mmol, 1 M in Et2O) was added dropwise tocrystallize the salt. The resulting HCl amine salt was then isolatedby filtration and washed with MTBE.
The synthetic route of 696-54-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Baucom, Kyle D.; Guram, Anil S.; Borths, Christopher J.; Synlett; vol. 26; 2; (2015); p. 201 – 204;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem